Main Article Content

Abstract

The study determined the anaesthetic and physiological effects of Acepromazine-Butorphanol-Propofol (ABP-combination) and propofol alone (PRO alone) in dogs. Ten clinically healthy dogs were randomly assigned to two groups to evaluate the anaesthetic and physiological effects following ABP-combination and PRO-alone anaesthesia administered intravenously (iv). Acepromazine at 0.02mg/kg and Butorphanol at 0.05mg/kg iv were used to premedicate the dogs and Propofol at 4mg/kg for induction five minutes after premedication in ABP-combination group while Propofol alone at 6mg/kg for total intravenous anaesthesia (TIVA) induction without premedication. Onset of anaesthesia, duration of anaesthesia time to standing, onset and duration of analgesia and duration of intubation were measured, whereas temperature, heart rate and respiratory rates were measured before induction of anaesthesia and at five minutes interval during anaesthesia. All the anaesthetic indices were significantly (p<0.05) different between groups while onset and duration of analgesia was recorded in ABP group only. Significantly (p<0.05) longer duration of anaesthesia was produced by ABP-combination compared with PRO-alone. Time to standing were significantly different (p<0.05) between the two treatments. The onset and duration of analgesia was 5.0±2.0 and 33.6±3.2 min. following ABP-combination but no analgesia recorded with PRO-alone. There was significant decrease (p<0.05) in rectal temperature and respiratory rate from the baseline in ABP-combination group but not significant in PRO-alone group. There was significant (p<0.05) difference in heart rates between groups. ABP-combination TIVA provided longer duration of anaesthesia and analgesia with minimal effects on vital parameters. The dogs recovered from the anaesthesia uneventfully. The ABP-combination can be evaluated for clinical procedures in dog.

Keywords

Acepromazine; Anaesthesia; Butorphanol; Dogs; Propofol

Article Details

Author Biographies

R. H. Gapsiso, Department of Animal Department of Animal Health and Production Technology, Federal Polytechnic Mubi. Adamawa State

Senior Lecturer in the Depasrtment of Animal Health and Production Technology

M. A. Umar, Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, University of Maiduguri, Born State, Nigeria.

Professor of Surgery and Anaesthesia

Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, University of Maiduguri, Born State, Nigeria.

A. Mohammed, Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, University of Maiduguri, Born State, Nigeria.

Profesor of Surgery

Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, University of Maiduguri, Born State, Nigeria.

How to Cite
Evaluation of Anaesthetic Indices and Physiological Variables Following Total Intravenous Anaesthesia with Acepromazine-Butorphanol-Propofol Combination in Dogs. (2023). Sahel Journal of Veterinary Sciences, 20(1), 44-49. https://doi.org/10.54058/saheljvs.v20i1.347

How to Cite

Evaluation of Anaesthetic Indices and Physiological Variables Following Total Intravenous Anaesthesia with Acepromazine-Butorphanol-Propofol Combination in Dogs. (2023). Sahel Journal of Veterinary Sciences, 20(1), 44-49. https://doi.org/10.54058/saheljvs.v20i1.347

References

  1. Adetunji, A., Ajadi, R, A., Adewoye, C. O. and ‎Onyemakinde, B. O. (2002). Total intravenous ‎anaesthesia with propofol repeat bolus versus ‎continous propofol infusion technique in ‎xylazine premedicated dogs. Israel Journal of ‎Veterinary Medicine, 57(4), pp.139-144.‎
  2. Anandmay, A. K., Dass, L. L. and Sharma, A. K. (2012). ‎Clinico-anaesthetic changes following ‎administration of propofol alone and in ‎comibnation of buprenorphine in dogs. Indian ‎Veterinary Journal, 89(10), pp.77-79.‎
  3. Bajwa, S. J., Bajwa, S. K. and Kaue, J. (2010). ‎Comparison of two drugs combination in total ‎intravenous anaesthetics: propofol-ketamine ‎and propofol-fentanyl. Saudi Arabian Journal ‎of Anaesthesia, 4(2), pp.72-‎‎79.DOI: 10.4103/1658-354X.65132‎
  4. Bolaji-Alabi, F.B. and Adetunji A. (2018). Anaesthetic ‎and cardiopulmonary parameters of dogs ‎administered propofol_acepromazine butorphanol or propofol- acepromazinebuprenophine ‎anaesthesia. Journal of Veterinary Medicine ‎and Animal Health. 10(7). pp.180 184. https://doi.org/10.5897/JVMAH2018.0682‎
  5. Branson, K. R. (2007). Injectable and alternative ‎anaesthetic techniques. In W. J. Tranquilli, and L. a. ‎Jones (Ed.), Veterinary Anaesthesia and Analgesia ‎‎(4th ed.,). Blackwell Publishing Limited. pp. 273-‎‎299.‎
  6. Bufalari, A., Miler, S. M., Short, C. E and Gianoni, G. ‎‎(1997). The use of propofol for induction of ‎anaesthesia in dogs premedicated with ‎acepromazine, butorphanol and acepromazine-‎butorphanol. New Zealand Veterinary Journal, ‎‎45(4), pp.129 134. https://doi.org/10.1080/0048016‎‎9.1997.36012
  7. Cattai, A., Rabozzi, R., Ferasin, H., Isola, M. and Franci, ‎P. (2018). Haemodynamic changes during propofol ‎induction in dogs. new findings and approach of ‎monitoring. BMC Veterinary Rsearch, 64(5), ‎pp.590-598.‎
  8. Cicek, M., Koroglu, A., Demirbilek, S., Teksan, H. and ‎Ersoy, M. O. (2005). Comparison of propofol-‎alfentanil andpropofol-remifentanil anaesthesia in ‎percutaneous nephrolithotripsy. European Journal ‎of Anaesthesiology, 22, pp.683-688. ‎‎ DOI: 10.1017/S0265021505001134‎
  9. Dzikiti, T. B., Stegmann, G. F., Hellenbrekers, L. J., Auer, ‎R. E. and Dzikiti. I. N. (2009). Sedative and ‎cardiopulmonary effects of acepromazine, ‎midazolam and butorphanol, acepromazine-‎butorphanol on propofol anaesthesia in goats. ‎Journal of South African Veterinary Association, ‎‎80(1), pp.10-‎‎16.https://doi.org/10.4102/jsava.v80i1.162‎
  10. Emmanuella, A.O.S., Adeniran, A. and Oluwaseun S.A., ‎‎(2020) Comparison of two neurolept agents on ‎propofol-isoflurane anaesthesized Nigerian ‎indigenous dogs. (2020). Alexandria Journal of ‎Veterinary Science, 65(1) pp. 96-101. DOI: ‎‎10.5455/ajvs.77317‎
  11. Elks, J. (2014). The dictionary of drugs: chemical data, ‎structures and bibliographies. Springer Science ‎Business Media. Dordrecht: pp.114.‎
  12. Forney, B. (2017). www. acepromazine maleate for ‎veterinary use. Retrieved Sptember 15, 2019, from ‎www.wedgewoodpetrx.com/learning-‎center/professional-mono.‎
  13. Hall, L. W., Clarke, K. W. and Trim, C. M. (2001). ‎Veterinary Anaesthesia (10th ed.). Edingburg, UK.: ‎WB Sauders. pp.80-97.‎
  14. IBM - Statistical package for social sciences, 2011 ‎‎(Version 20.0).‎
  15. Kajoma K., Nishimura, R., Mutoh, T., Hong, S. H., ‎Mochizuki , M. and Sasaki, N. (2002). Effect of ‎medetomidine-midazolam, acepromazine-‎butorphanol and midazolam-butorphanol on ‎induction dose of thiopental and propofol and on ‎cardiopulmonary changes in dogs. American ‎Journal of Veterinary Research, 63(12), pp.1671-‎‎1679.https://doi.org/10.2460/ajvr.2002.63.1671‎
  16. Matthews N.S. (2007). Inhalant anaesthetics. In Chris ‎Seymour, BSAVA Manual of Canine and Feline ‎Anaesthesia andAnalgesia 2nd ed., 21(1) pp 47 -‎‎ 48. Gloucester: British Small Animal Veterinary ‎Association.‎
  17. Merik. E. P. (2004). Propofol: therapeutic indication and ‎the side effects:. Current Pharmaceutical design., ‎‎10(29), pp.3639-3649. ‎http://dx.doi.org/10.2174/1381612043382846‎
  18. Mohammad, N., Zafar, M.A., Mohammad, G., Masood, ‎M. Z., Manzoor, A. and Sarfaraz. I. ‎‎(2009).Comparative efficacy of propofol, ‎thiopental sodium and combination ofpropofol with ‎ketamine hydrochloride in dogs. Pakistani ‎Veterinary Journal, 29(1), pp.11-15.‎
  19. Morton. I. K. and Hall, J. M. (2012). Concise Dictionary ‎of Pharmacological Agents: Properties and ‎Synonyms. Neitherlands: Springer Science and ‎Business Media. ‎pp.101.https://link.springer.com/book/10.1007/978-‎‎94-011-4439-1Musk, G. C., Pang, D. S., Beths, T. ‎and Flaherty, D. A. (2005). Target-controlled ‎infusion ofpropofol in dogs: evaluation of four ‎targets for induction of anaesthesia. TheVeterinary ‎Records, 157, pp.766-‎‎770.https://doi.org/10.1136/vr.157.24.766
  20. Radney, D.I. and Smith, L.J. (2018). Comparison of the ‎effects of alfaxalone and propofol with ‎acepromazine, butorphanol and or doxaphram on ‎laryngeal motion and quality of examination in ‎dogs. Veterinary Anaesthesia and Analgesia. ‎‎45(3)pp.241-‎‎249.https://doi.org/10.1016/j.vaa.2017.08.014‎
  21. Salla, K. Bennett, R.C., Restitutti, F., Junnila, J., Raekallio, ‎M. and Vainio, O. (2014). A comparison in dogs of ‎meditomidine with or without MK-467 and the ‎combination acepromazine-butorphanol as ‎premedication prior to anaesthesia induced by ‎propofol and maintained with isoflurane. ‎Veterinary Anaesthesia and Analgesia. ‎‎41(2)pp.163-173. DOI: https//doi.org/10.111/vaa ‎‎12094‎
  22. Smith, J. A., Gaynor, J. S., Bednarski, R. M. and Muir ‎W.W. (1993). Adverse effect of administration of ‎propofol with various preanaesthetic regiments in ‎dogs. Journal of American Veterinary Medical ‎Association, 202(7) pp.1111-1115.‎
  23. Stephanie . C. D., Stephanie, A.K., Christopher, K.S, ‎Sayge, M.S., Xiaojuan, Z and Reza, S. (2022). ‎Effects of intravenous acepromazine and ‎butorphanol on propofol dosage for induction of ‎anaesthesia in healthy Beagle dogs. Veterinary ‎Anaesthesia and Analgesia, 49(4):pp. 354-‎‎363.https://doi.org/10.1016/j.vaa.2022.03.002‎
  24. Thurmon, J. C. and Short, C. E. (2007). History and ‎overview of veterinary anaesthesia. In G. K. C., ‎Lumbs and JonesVeterinary Anaesthesia and ‎Analgesia (4th ed.,). Oxford: Blackwell Publishing ‎Ltd. pp.3-6.‎
  25. Tsai, Y. C., Wang, L. Y. and Yeh, L. S. (2007). Clinical ‎comparison of recovery from totalintravenous ‎anaesthesia with prpofol and inhalational ‎anaesthesia with isoflurane in dogs. The Journal of ‎Veterinary Medical Science/ Japanese Society of ‎Veterinary Science., 69, pp.1179-‎‎1182.https://doi.org/10.1292/jvms.69.1179‎
  26. Umar, M. A., Yamashita, K., Kushiro, T. and Muir, W. W. ‎‎(2006). Evaluation of total intravenous anaesthesia ‎with propofol or ketamine-meditomidine-‎propofolcombination in horses. Journal of ‎American Veterinary Medical Association., 228(8), ‎pp.1221-‎‎1227.https://doi.org/10.2460/javma.228.8.1221‎
  27. Umar, M. A., Yamashita, K., Kushiro, T. and Muir, W. W. ‎‎(2007). Evaluation of cardiovascular effects of ‎total intravenous anaesthesia with propofol or a ‎combimation of ketamine-meditomidine-propofol ‎in horses. Asian Journal of Veterinary Research, ‎‎68(2), pp.121-‎‎126.https://doi.org/10.2460/ajvr.68.2.121‎
  28. Waelbers, Y., Vermoere, P, and Polis, I. (2009). Total ‎intravenous anaesthesia in dogs:. Diergenees ‎Kundig Tijdschrift Journal, 78, pp.160-169.‎
  29. Yamashita, K. Wijayathilaka, T. P., Kushiro, T., Umar, M. ‎A., Taguchi and Muir, W. W. (2007). Anaesthetic ‎and cardiopulmonary effects of total intravenous ‎anaethesia using midazolam, ketamine and ‎meditomidine drug combination in horses. Journal ‎of Veterinary Medical Science, 69(1), pp.7-‎‎13.https://doi.org/10.1292/jvms.69.7‎