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Abstract

The correlations of reduced glutathione (GSH) and glutathione peroxidase (GPx) levels with biochemical markers of liver and kidney damage in Trypanosoma brucei brucei infection were studied in rats. Forty adult male rats divided into 2 groups of control and infected were used. Infected rats were inoculated intraperitoneally with 1.0 ml of blood at concentration of 1 x 106 trypanosomes per ml. Serum and tissue samples were collected on days 0, 3, 5 and 7 post-infection (pi) for biochemical analyses. Serum GPx activity had a significant (p < 0.05) positive correlations with liver (r = 0.96) and kidney GSH (r = 0.93) levels. All the measured serum parameters had significant (p < 0.05) negative correlations with serum GPx activity. In conclusion infection of rats with T. brucei brucei caused a decrease in the serum GPx activities and organ GSH levels with increasing parasitaemia and duration of the infection.

Keywords

Trypanosoma brucei brucei; Oxidative stress; Glutathione peroxidase; Glutathione; Liver and kidney function

Article Details

Author Biographies

J. P. Erin, Department of Veterinary Pathology Ahmadu Bello University Zaria

Department of Veterinary Pathology

S. Y. Idris, Ahmadu Bello University, Zaria

Lecturer II Department of Veterinary Pathology ABU Zaria, Nigeria

B. J. Kolawole, Michael Okpara University of Agriculture, Umudike, Abia State.

Department of Veterinary Medicine

O. G. Fanaiye, Dept of Theriogenology and Production, ABU Zaria.

Dept of Theriogenology and Production

S. Adamu, Ahmadu Bello University Zaria

Department of Veterinary Pathology

K. A. N. Esievo, Ahmadu Bello University Zaria

Veterinary Pathology

How to Cite
Correlations of Reduced Glutathione and Glutathione Peroxidase Activities with Biochemical Markers of Liver and Kidney Damage in Trypanosoma brucei brucei Infected Rats. (2020). Sahel Journal of Veterinary Sciences, 17(2), 1-6. https://doi.org/10.54058/saheljvs.v17i2.95
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How to Cite

Correlations of Reduced Glutathione and Glutathione Peroxidase Activities with Biochemical Markers of Liver and Kidney Damage in Trypanosoma brucei brucei Infected Rats. (2020). Sahel Journal of Veterinary Sciences, 17(2), 1-6. https://doi.org/10.54058/saheljvs.v17i2.95

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