Main Article Content

Abstract

Q fever is a bacterial zoonotic disease caused by Coxiella burnetiiwith global epidemiology. Transmission of the disease in humans is mainly via inhalation of aerosolized bacteria and consumption of contaminated unpasteurized milk, while in animals it is through ingestion of contaminated pasture during grazing by susceptible animals. The disease is usually asymptomatic in animals, but has been implicated in abortion, stillbirths, endometritis, mastitis and infertility. In humans, it manifests as acute and chronic forms with the acute form having signs as self-limiting flu-like syndrome, pneumonia and hepatitis. Diagnosis is mainly through serology using ELISA, CFT, dot immunoblotting, and molecular assay. This study aimed at reviewing the literature to provide relevant information on the epidemiology and risk factors of Coxiella infection in Nigeria. The disease had been reported in all the geopolitical zones of Nigeria and it is said to have no breed, sex and age predisposition. Some of the risk factors identified to play vital roles in the epidemiology of the disease in Nigeria include husbandry and management practices, transboundary transfer of animals, poor hygiene at abattoirs as well as poor knowledge, attitude, and practices by livestock owners and abattoir personnel. It is recommended that there should be public enlightenment along with continuous education of stakeholders in the livestock industry on the significance of the disease.

Keywords

Coxiella infection;Epidemiology; Public health; Risk factors

Article Details

How to Cite
The Epidemiology of Coxiella infections in Domestic Animals and Humans in ‎Nigeria: A Review. (2023). Sahel Journal of Veterinary Sciences, 20(1), 1-12. https://doi.org/10.54058/saheljvs.v20i1.355

How to Cite

The Epidemiology of Coxiella infections in Domestic Animals and Humans in ‎Nigeria: A Review. (2023). Sahel Journal of Veterinary Sciences, 20(1), 1-12. https://doi.org/10.54058/saheljvs.v20i1.355

References

  1. Adamu, S.G., Tijani, A.O., Adamu, N.B., Atsanda, N.N., ‎Dauda, J. and Lawan, F.A., (2019). Epidemiology ‎of Q fever in flocks of sheep in Yobe State, ‎Nigeria. J. Vet. Biomed. Sci, 2(1), pp.70-76‎
  2. Adamu S. G., Kabir J., Umoh J. U., and Raji M. A. (2018). ‎Seroprevalence of brucellosis and Q fever ‎‎(coxiellosis) in cattle herds in Maigana and ‎BirninGwariagro-ecological zones of Kaduna State, ‎Nigeria. Tropical Animal Health and production. ‎‎50: 1583–1589. pmid:29675780. ‎
  3. Adamu, S. G., Kabir, J., Umoh, J. U., and Raji, M. A. (2021). ‎Seroprevalence of Coxiellaburnetii in sheep flocks ‎in Kaduna State, Northwestern Nigeria. Acta ‎Veterinaria Hungarica, 59(3): 234-238. ‎https://doi.org/10.1556/004.2021.00034‎
  4. Addo, P. B. and Schnurenberger, P. R. (1977). Q fever ‎antibodies in food animals of Nigeria: a serological ‎survey of cattle, sheep and goats. Revue de Elevage ‎et de Medicine Veterinaire des Pays Tropicaux, ‎‎30(4): 359–362.‎
  5. Adesiyun, A. A., Jagun, A. G. and Tekdek, L. B. (1984). ‎Coxiella burnetii antibodies in some Nigerian dairy ‎cows and their suckling calves. International ‎Journal of Zoonoses, 11 (2): 155–60.‎
  6. Adesiyun, A.A., Jagun, A.G., Kwaga, J.K., and Tekdek, ‎L.B. (1985). Shedding of Coxiella burnetii in milk ‎by Nigerian dairy and dual purposes cows ‎International Journal of Zoonoses, 12 (1): 1-5.‎
  7. Adu-Addai, B, Koney, E. B, Addo, P, Kaneene, J, and ‎Mackenzie C, (2012). Importance of infectious ‎bovine reproductive diseases: an example from ‎Ghana. Veterinary Records, 171: 47–47.‎
  8. Amal S. M. S., Asmaa, A. A. H., Ismail, A. A., Nasr, S. E. M. ‎and Yasukazu, M. (2002) Prevalence of Coxiella ‎burnetii infection among dogs and humans in ‎Upper Egypt. Assiut Veterinary. Medical ‎Journal, 47: 205–215.‎
  9. Amin, W. F. and Ahmed, S. O. (2009). Detection of Coxiella ‎burnetii in bovine milk samples using polymerase ‎chain reaction. Assiut Veterinary. Medical ‎Journal 55: 23–31.‎
  10. Angelakis,E. and Raoult, D. (2010). Q fever. Veterinary ‎Microbiology. 140: 297–309. ‎doi:10.1016/j.vetmic.2009.07.016.‎
  11. Asadi, J., Kafi, M. and Khalili, M. (2013). Seroprevalence of ‎Q fever in sheep and goat flocks with a history of ‎abortion in Iran between 2011 and 2012. Asian ‎Pacific journal of tropical biomedicine,49(2): ‎‎163–168. doi:10-12980/APJTB.4.2014C1268.‎
  12. Anstey, N. M., Tissot D. H., Hahn, C. G., Mwaikambo, E. D. ‎and McDonald, M. I. (1997). Seroepidemiology ‎of Rickettsia typhi, spotted fever group rickettsiae, ‎and Coxiella burnetti infection in pregnant women ‎from urban Tanzania. The American journal ‎of tropical medicine and hygiene, 57: 187–189.‎
  13. Baba, A. Y. (2019). Clinico-epidemiological studies of ‎brucellosis in horses in Kano metropolis, Kano ‎State, Nigeria. PhD thesis submitted to Ahmadu ‎Bello University, Zaria, Nigeria. 190 pages.‎
  14. Behymer, D. and Riemann, H. P. (1989). Coxiella ‎burnetii infection (Q fever). Journal of American ‎Veterinary Medical Association, 194: 764–767.‎
  15. Benkirane, A., Jabli, N. and Rodolakis, A. (1990). Frequency ‎of abortion and seroprevalence of the principal ‎diseases causing ovine infectious abortion in the ‎area of Rabat (Morocco). Annales de recherches ‎veterinaries,21: 267–273.‎
  16. Benslimani, A., Fenollar, F., Lepidi, H. and Raoult, D. ‎‎(2005). Bacterial zoonoses and infective ‎endocarditis, Algeria. Emerging Infectious ‎Diseases, 11: 216–224. ‎
  17. Berri, M., Rekiki, A., Boumedine, K. S. and Rodolakis, A. ‎‎(2009). Simultaneous differential detection ‎of Chlamydophila abortus, Chlamydophila ‎pecorum and Coxiella burnetii from aborted ‎ruminant's clinical samples using multiplex ‎PCR. BMC Microbiology, 9: 130.‎
  18. Blondeau, J. M., Williams, J. C. andMarrie, T. J. (1990a). ‎The immune response to phase I and phase ‎II Coxiella burnetii antigens as measured by ‎Western immunoblotting. Annals of the New York ‎Academy of Sciences, 590:187–202.‎
  19. Blondeau, J., Yates, L., Martin, R., Marrie, T., Ukoli, P. and ‎Thomas, A. (1990b). Q Fever in Sokoto, Nigeria. ‎Annals of the New York Academy of Sciences, 590: ‎‎281–282. pmid:2378458‎
  20. Brezina, R. (1976). Phase variation phenomenon in Coxiella ‎burnetii, p. 221-235. In J. Kazar, R. A. Ormsbee, ‎and I. Tarasevitch, (ed.), Rickettsia and ‎Rickettsiales disease. Veda, Bratislava, Slovakia.‎
  21. Brouqui, P., Dupont, H. T., Drancourt, M., Berland, Y. and ‎Etienne, J. (1993). Chronic Q fever. Ninety-two ‎cases from France, including 27 cases without ‎endocarditis. Archives of internal medicine,153: ‎‎642–648. ‎
  22. Buhari H U. (2014). Survey of bovine brucellosis in the ‎North Senatorial district of Kaduna State, Nigeria. ‎MSc Dissertation to Ahmadu Bello University, ‎Zaria.111 pages.‎
  23. Buhari, U H (2019). Epidemiology of brucellosis in small ‎ruminants in two institutional farms and a ‎slaughter’s slab in Zaria, Kaduna State, Nigeria. ‎PhD thesis to Ahmadu Bello University, Zaria, ‎Nigeria. 148 pages.‎
  24. Burnet, F. M. and Freeman, M. (1937). Experimental studies ‎on the virus of Q fever. Medical Journal of ‎Australia, 2: 299-305.‎
  25. Cadmus, S I., Kelechi, A. A., Fiyinfoluwa, O., Olubukola, ‎D.A. and Victor, O. A. (2020). Seroprevalence and ‎associated factors of brucellosis and Q-fever in ‎cattle from Ibarapa area, Oyo State, South-western ‎Nigeria. Pan African Medical Journal, 36(1): 370-‎‎381.doi:10.11604/pamj.2020.36.370.24925. ‎
  26. Cadmus S. I., Salam S. P., Adesokan, H. K., Akporube, K., ‎Ola-Daniel, F. and Awosanya, E. J. (2021). ‎Seroprevalence of brucellosis and Q fever ‎infections amongst pastoralists and their cattle ‎herds in Sokoto State, Nigeria. PLOS ONE 16(7): ‎https://doi.org/10.1371/journal.pone.0254530‎
  27. CDC, (1999). Diagnosis and management of Q fever in ‎United State of America. ‎http://www.cdc.gov/qfever/symptoms/index.html. ‎Accessed online 15th June, 2022.‎
  28. CDC (2021).http://www.cdc.gov/qfever/symptoms/index.html. Accessed 21th December, 2021‎
  29. Center for Food Security and Public Health (CFSPH) (2007). ‎Q fever. Institute for International Cooperation in ‎Animal Biologics an OIE Collaborating Center ‎College of Veterinary Medicine Iowa State ‎University Ames, Iowa 50011. ‎http://www.cfsph.iastate.edu, 1–2.‎
  30. Center for Disease Control and prevention (2013). ‎Symptoms, Diagnosis, and Treatment of Q ‎fever. http://www.cdc.gov/qfever/symptoms/index.‎html
  31. Cooper, A., Stephens, J., Ketheesan, N. and Govan B. ‎‎(2013). Detection of Coxiella burnetii DNA in ‎Wildlife and Ticks in Northern Queensland, ‎Australia. Vector-BorneandZoonotic Diseases, ‎‎13(1): 12-16. ‎https://doi.org/10.1089/vbz.2011.0853‎
  32. Cowley, R., Fernandez, F., Freemantle, W. and Rutter, D. ‎‎(1992). Enzyme immunoassay for Q fever: ‎comparison with complement fixation and ‎immunofluorescence tests and dot ‎immunoblotting. Journal of Clinical Microbiology, ‎‎30: 2451–2455.‎
  33. Corwin, A., Habib, M., Watts, D., Darwish, M. and Olson J. ‎‎(1993). Community-based prevalence profile of ‎arboviral, rickettsial, and Hantaan-like viral ‎antibody in the Nile River Delta of Egypt. The ‎American journal of tropical medicine and ‎hygiene, 48: 776–783.‎
  34. Cutler, S. J., Bouzid,M. and Cutler R. R. (2007). “Q ‎fever,” Journal of Infection, 54(4): 313–318.‎
  35. Danbirni, S., Daudu, B. B., Saidu, S. N. A. and Tekdek, L. B. ‎‎(2018).Assessment of Farm management risk ‎factors of contracting haemoparasitic infections in ‎Pastoralist and Sedentary cattle in Soba Local ‎Government Area, Kaduna State, Nigeria. Nigerian ‎Journal Animal Production, 45(4): 28 - 36‎
  36. Davis, G. E. and Cox, H. R. (1938). A filter-passing ‎infectious agent isolated from ticks. I. Isolation ‎from Dermacentorandersonii, reactions in animals, ‎and filtration. Public Health Reports, 53(52): ‎‎2259–2282.‎
  37. Dean, A. S., Bonfoh, B., Kulo, A. E., Boukaya, G. A., ‎Amidou, M.and Hattendorf, J.(2013). ‎Epidemiology of brucellosis and Q fever in linked ‎human and animal populations in Northern Togo. ‎PLoS One, 8(8):1–8. pmid:23951177‎
  38. de Lange, M. M. A, Hukkelhoven, C. W. P. M., Munster, J. ‎M., Schneeberger, P. M., and
  39. Hoek, W. (2015). Nationwide registry-based ecological ‎analysis of Q fever incidence and pregnancy ‎outcome during an outbreak in the ‎Netherlands. BMJ Journal, doi:10.1136/bmjopen-‎‎2014-006821.‎
  40. Derrick, E. H. (1973). The course of infection with Coxiella ‎burneti. Medical Journal of Australia, 1: 1051–‎‎1057. ‎
  41. Doller, G., Doller, P. C. andGerth, H. J. (1984).Early diagnosis ‎of Q fever: detection of immunoglobulin M by ‎radioimmunoassay and enzyme ‎immunoassay. European journal of clinical ‎microbiology & infectious diseases, 3: 550–553.‎
  42. Domenech, J,Trap, D.and Gaumont R. (1985). Study of ‎reproductive pathology in cattle in Central Africa: ‎survey of chlamydiosis and Q fever. Revue ‎D'élevage et de MédecineVétérinaireDes Pays ‎Tropicaux,38: 138–143.‎
  43. Domingo, P.,Munoz, P., Franquet,C.,Gurguí,T., Sancho M.F. ‎and Vazquez, G. (1999).Acute Q fever in adult ‎patients: report on 63 sporadic cases in an urban ‎area,” Clinical Infectious Diseases, 29(4): 874–‎‎879.‎
  44. Dupuis, G., Petite, J., Peter, O. and Vouilloz, M. (1987).An ‎important outbreak of human Q fever in a Swiss ‎Alpine valley. International journal of ‎epidemiology, 16: 282–287. ‎
  45. Eldin, C., Melenotte, C., Million, M., Cammilleri, S., Sotto, ‎A., Elsendoorn, A., Thuny, F., Lepidi, H., Roblot, F., ‎Weitten, T., Assaad, S., Bouaziz, A., Chapuzet, C., ‎Gras, G., Labussière, S., Landais, C., Longuet, P., ‎Masseau, A., Mundler, O. and Raoult, D. ‎‎(2016). 18F-FDG PET/CT as a central tool in the ‎shift from chronic Q fever to Coxiella burnetii ‎persistent focalized infection. Medicine ‎‎(Baltimore), 95(34): e4287. ‎doi:10.1097/MD.0000000000004287. ‎
  46. Eldin, C., CléaMélenotte, O. M., Eric, G., Matthieu, M., ‎Sophie, E., Jean-Louis, M., Max, M. and Didier, R. ‎‎(2017). From Q Fever to Coxiella ‎burnetii Infection: a Paradigm Change Clinical ‎Microbiology Reviews, 30(1): 115–190.‎
  47. Elelu N, Bankole A. A, Musa, R. J., Odetokun, I. A., Rabiu, ‎M. and Biobaku, K.T. (2020). Serospatial ‎epidemiology of zoonotic Coxiella burnetii in a ‎cross section of cattle and small ruminants in ‎Northern Nigeria. PLoS ONE 15(10): ‎https://doi.org/10.1371/journal.pone.0240249.‎
  48. Epelboin, L., Chesnais, C., Boulle, C., Drogoul, A. S. ‎andRaoult, D. (2012). Q fever pneumonia in French ‎Guiana: prevalence, risk factors, and prognostic ‎score. Clinical Infectious Diseases 55: 67–74.‎
  49. European Food Safety Authority (EFSA) (2010), ‎‎“Development of harmonized schemes for the ‎monitoring and reporting of Q fever in animals in ‎the European Union,” Technical Report. EFSA-Q-‎‎2009–00511.‎
  50. Fenollar, F., P. Fournier, M. Carrieri, G. Habib, T. Messana, ‎and D. Raoult. (2001). Risks factors and prevention ‎of Q fever endocarditis. Clinical Infectious ‎Diseases, 33(3): 312-316. ‎https://doi.org/10.1086/321889‎
  51. Fenollar, F.,Fournier,P. E. and Raoult,D. (2004). Molecular ‎Detection of Coxiella burnetii in the Sera of ‎Patients with Q Fever Endocarditis or Vascular ‎Infection. Journal of Clinical ‎Microbiology,42(11): 4919–4924.‎
  52. Fishbein D. B, and Raoult, D. (1992). A cluster of Coxiella ‎burnetii infections associated with exposure to ‎vaccinated goats and their unpasteurized dairy ‎products. The American journal of tropical ‎medicine and hygiene, 47: 35–40.‎
  53. Fournier, P., Marrie, T. and Raoult. D. (1998). Diagnosis of Q ‎fever. Journal of Clinical Microbiology, 36: 1823-‎‎1834. ‎
  54. Fournier, P. and Raoult. D. (2003). Comparison of PCR and ‎serology for the diagnosis of acute Q fever. Journal ‎of Clinical Microbiology 41: 5094-5098.‎
  55. Fournier, P., Casalta, J., Piquet, P.Tournigand, P. ‎Branchereau, A. and Raoult, D. (1998). Coxiella ‎burnetii infection of aneurysms or vascular grafts: ‎report of seven cases and review. Clinical ‎Infectious Diseases, 26: 116-121.‎
  56. Gidel, R., Lefevre, M.andAthawet, B. (1966). Investigation ‎on the epidemiology of rickettsiosis in a rural ‎section of the Ivory Coast. Medical Tropical ‎‎(Mars) 26: 649–661.‎
  57. Gidel R. and Athawet, B. (1975). Serological survey of ‎human brucellosis and rickettsial diseases in a ‎group of a nomad population in the sahelian ‎regions of Upper Volta. Annales de la Societe Belge ‎de MedecineTropicale, 55: 77–83.‎
  58. Gomez-Aranda, F., Pachon Diaz, J., Romero Acebal, M., ‎Lopez Cortes, L., Navarro Rodriguez,Maestre,A., ‎Moreno, J. (1984). Computed tomographic brain ‎scan findings in Q fever ‎encephalitis. Neuroradiology. 26: 329–332. ‎
  59. Gozalan A., Rolain, J. M., Ertek, M., Angelakis E., Coplu, N. ‎andBasbulut, E. A. (2010). Seroprevalence of Q ‎fever in a district located in the west Black Sea ‎region of Turkey. European journal of clinical ‎microbiology & infectious diseases, 29: 465–469. ‎
  60. Gummow, B., Poerstamper, N. and Herr, S. (1987). The ‎incidence of Coxiella burnetii antibodies in cattle ‎in the Transvaal. Onderstepoort. Journal of ‎Veterinary Medical Research,54: 569–571.‎
  61. Harrell, G. T. (1953). Rickettsial involvement of the central ‎nervous system. The Medical clinics of North ‎America,37:395–422.‎
  62. Haumesser, J. B. andPoutrel, B. (1973). Rickettsiosis in the ‎Niger. Epidemiological investigation carried out in ‎the Maradi area. Revue d'Elevage et de ‎MédecineVétérinaire des Pays Tropicaux, 26: 293–‎‎298.‎
  63. Honarmand, H. (2012). Q Fever: An Old but Still a Poorly ‎Understood Disease. https://doi.org/10.1155/2012/‎‎131932.‎
  64. Horigan, M. W., Bell, M. M., Pollard, T. R., Sayers, A. R. and ‎Pritchard, G. C. (2011). Q fever diagnosis in ‎domestic ruminants: comparison between ‎complement fixation and commercial enzyme-‎linked immunosorbent assays. The Journal of ‎Veterinary Diagnostic Investigation, 23(5): 924–‎‎931. pmid:21908348.‎
  65. Higgins, D. and Marrie,T. J. (1990). Seroepidemiology of Q ‎fever among cats in New Brunswick and Prince ‎Edward Island. Annals of the New York Academy of ‎Sciences, 590: 271–274. ‎
  66. Hussien, M. O., ElFahal, A. M., Enan, K. A., Taha, K. M., ‎Mohammed, M. S. (2012). Seroprevalence of Q ‎fever in goats in the Sudan. Veterinary World, 5: ‎‎394–397.‎
  67. Julvez, J., Michault, A. and Kerdelhue, C. (1997). Serological ‎study of rickettsioses in Niamey, Niger./Étude ‎sérologique des rickettsioses a Niamey, ‎Niger. Medical Tropical (Mars), 57: 153–156. ‎
  68. Kaabia, N., Rolain, J. M., Khalifa, M., Ben Jazia, E. and ‎Bahri, F. (2006). Serologic study of rickettsioses ‎among acute febrile patients in central ‎Tunisia. Annals of the New York Academy of ‎Sciences, 1078: 176–179. ‎
  69. Kabir, S. G., Umoh,,J. U. and Raji M A. (2021). ‎Seroprevalence of Coxiella burnetii in sheep flocks ‎in Kaduna State, Northwestern Nigeria. 69(3): 234–‎‎238. Doi: https://doi.org/10.1556/004.2021.00034‎
  70. Kaltungo, B. Y. (2013). Survey of Brucellosis in sheep and ‎goats in Kaduna North Senatorial district of ‎Kaduna State, Nigeria. MSc Dissertation submitted ‎to Department of Veterinary Medicine, Ahmadu ‎Bello University, Zaria. 155 pages‎
  71. Kaltungo, B. Y. (2018a).Serological and participatory ‎studies of Brucella infections in Small Ruminants ‎in Katsina and Sokoto State, Nigeria. PhD thesis ‎submitted to Department of Veterinary Medicine, ‎Ahmadu Bello University, Zaria 188 pages.‎
  72. Kaltungo, B. Y. (2018b). Sero-prevalence and risk factors ‎for Brucella melitensis in camels in two Local ‎Government Areas of Katsina State, Nigeria. ‎Project dissertation submitted to the Faculty of ‎Medicine, College of Veterinary Surgeons Nigeria, ‎Zaria Study Centre, Ahmadu Bello University, ‎Zaria. 56 pages.‎
  73. Kamga-Waladjo, A. R., Gbati, O. B., Kone, P., Lapo, R. A. ‎and Chatagnon, G. (2010). Seroprevalence ‎of Neospora caninum antibodies and its ‎consequences for reproductive parameters in dairy ‎cows from Dakar-Senegal, West Africa. Tropical ‎Animal Health Production, 42: 953–959.‎
  74. Kanoute, Y. B., Gragnon, B. G., Schindler, C., Bonfoh, B. ‎and Schelling, E. (2017). Reprint, of “Epidemiology ‎of brucellosis, Q fever and Rift Valley Fever at the ‎human and livestock interface in northern Cote ‎d’Ivoire”. Acta Tropica, 175: 121–129. ‎pmid:2886739 ‎
  75. Kazar, J., Brezina, R., Schramek, S.,Palanova, A. and Tvrda, ‎B. (1981). Suitability of the microagglutination test ‎for detection of post-infection and post-‎vaccination Q fever antibodies in human sera. Acta ‎Virology, 25: 235–240.‎
  76. Kersh, G. J., Priestley, R. and Massung, R. F. (2013). Stability ‎of Coxiella burnetii in stored human blood. The ‎Journal of AABBTransfusion (Paris), 53: 1493–‎‎1496. doi:10.1111/j.1537-2995.2012.03912x.‎
  77. ‎ Khalili,M., Morteza, M.,Hamzeh, G. D. and Hossein, N. M. ‎‎(2014). Serologic survey for Coxiella ‎burnetii phase II antibodies among slaughterhouse ‎workers in Kerman, southeast of Iran. Asian ‎Pacific Journal of Tropical Biomedicine, 4(1): ‎S209-S212. ‎https://doi.org/10.12980/APJTB.4.2014C1268.‎
  78. Khalili, M., Shahabi-Nejad, N. and Golchin, M. (2010). Q ‎fever serology in febrile patients in Southeast ‎Iran. Transactions of the Royal Society of Tropical ‎Medicine and Hygiene, 104: 623–624.‎
  79. Khademi, P., Ownagh,A., Ataei,B.,Kazemnia,A.J., EydiKhalili, M., Mahzounieh, M.and Mardani,K. (2020). ‎Molecular detection of Coxiella burnetii in horse ‎sera in Iran. Comparative Immunology, ‎Microbiology and Infectious Diseases, 72: ‎https://doi.org/10.1016/j.cimid.2020.101521‎
  80. Ki-Zerbo, G. A., Tall, F., Nagalo, K., Ledru, E. and Durand G. ‎‎(2000). Rickettsiosis and Q fever in pyretic patients ‎hospitalized at the Bobo- Dioulasso Hospital ‎‎(Burkina Faso). Medical malpractice,30: 270–274.‎
  81. Kobbe, R., Kramme, S., Kreuels, B., Adjei, S. and Kreuzberg, ‎C. (2008). Q fever in young children, ‎Ghana. Emerging Infectious Diseases. 14: 344–‎‎346.‎
  82. Koulla-Shiro, S., Kuaban, C. and Belec, L. (1996). Acute ‎community-acquired bacterial pneumonia in ‎human immunodeficiency virus (HIV) infected and ‎non-HIV-infected adult patients in Cameroon: ‎Aetiology and outcome. Tubercle and Lung ‎Disease,77(1): 47–51. ‎https://doi.org/10.1016/S0962-8479(96)90075-1‎
  83. Koulla-Shiro, S., Kuaban, C. andBelec, L. (1997). Microbial ‎etiology of acute community-acquired pneumonia ‎in adult hospitalized patients in Yaounde-‎Cameroon. Clinical Microbiology and Infection, 3‎‎(2): 180–186.https://doi.org/10.1111/j.1469-‎‎0691.1997.tb00595.x‎
  84. Kudi, C. A. (2016). Seroprevalence of bovine tuberculosis ‎and brucellosis infection in agropastoralists ‎livestock herds and wildlife in Yankari Game ‎Reserve. Project to College Veterinary Surgeons ‎Nigeria in fulfilment for Fellowship Award.‎
  85. Kyle, A., Donnelly, M. A., Miller, Douw, G., Peter, ‎B., Charles, V. N., Léanie, K., Tanya, J., Kerr, S.and ‎Citino, B. (2021). Serological evidence of ‎Coxirllaburnettii infection in the white Rhinoceros ‎‎(Ceratheriumsimium) in South Africa Journal of ‎Zoo and Wildlife Medicine, 52(2): 573-‎‎579. https://doi.org/10.1638/2020-0154‎
  86. Lawan, M. K, Bello, M. and Raji, M. A. (2010). The public ‎health implications of the operational activities of ‎butchers in abattoirs. Paper presented at the ‎Nigerian Veterinary Medical Association Annual ‎Congress held vat the Auditorium, College of ‎Health Sciences, Benue State University, Benue ‎State, Nigeria between 4th and 8th October, 2010.‎
  87. Langley, J. M., Marrie, T. J., Covert, A., Waag, D. M. and ‎Williams, C. (1988). Poker players’ pneumonia. An ‎urban outbreak of Q fever following exposure to a ‎parturient cat. The New England Journal of ‎Medicine, 319:354–355. ‎https://doi.org/10.1056/NEJM198808113190607‎
  88. Lieberman, D., Boldur, I., Manor, E., Hoffman, S., ‎Schlaeffer, F. and Porath, A. (1995). Q-fever ‎pneumonia in the negev region of Israel: a review ‎of 20 patients hospitalised over a period of one ‎year. The Journal of Infection, 30: 135–140.‎
  89. Maartens, G., Lewis, S. J., de Goveia, C., Bartie, C. ‎andRoditi, D. (1994). ‘Atypical’ bacteria are a ‎common cause of community-acquired ‎pneumonia in hospitalised adults. South African ‎Medical Journal, 84(10): 678–682.‎
  90. Madariaga, M. G., Rezai, K., Trenholme, G. M. and ‎Weinstein, R. A. (2003). Q fever: a biological ‎weapon in your backyard. The Lancet Infectious ‎Diseases, 3(11): 709-721. ‎https://doi.org/10.1016/S1473-3099(03)00804-1‎
  91. Marrie, T. J. (1990). Historical aspects of Q fever.In: Q ‎Fever, Volume I: The Disease, Ed., CRC Press, Boca ‎Raton, Fla, USA
  92. Marrie, T. J. (2010). “Q fever pneumonia,” Infectious ‎Disease Clinics of North America. 24(1): 27–41. ‎https://doi.org/10.1016/j.idc.2009.10.004‎
  93. Marrie T J, MacDonald, A., Durant, H., Yates, L. and ‎McCormick, L. (1988). An outbreak of Q fever ‎probably due to contact with a parturient ‎cat. Chest. 93(1): 98–‎‎103. https://doi.org/10.1378/chest.93.1‎
  94. Maurice, Y., Fernagut, R. and Gerome, R. (1968). Rickettsial ‎diseases of North Cameroon; epidemiological ‎study. Revue d'Elevage et de MédecineVétérinaire ‎des Pays Tropicaux, 21(3): 341–349.‎
  95. Maurin, M., and D. Raoult. (1999). Q fever. Clinical ‎Microbiology Reviews,12(4): 518-‎‎553. https://doi.org/10.1128/CMR.12.4.518‎
  96. Metanat, M., Sepehri Rad, N., Alavi-Naini, R., Shahreki, S., ‎Sharifi-Mood, B. and Akhavan, A. (2014). Acute Q ‎fever among febrile patients in Zahedan, ‎Southeastern Iran. Turkish Journal of Medical ‎Sciences, 44: 99–103. https://doi.org/10.3906/sag-‎‎1209-102‎
  97. Morita, C., Katsuyama, J., Yanase, T., Ueno, H., ‎Muramatsu, Y., Hohdatsu, T. and Koyama, H. ‎‎(1994). Seroepidemiological survey of Coxiella ‎burnetii in domestic cats in Japan. Microbiology ‎and Immunology, 38(12): 1001–1003. ‎
  98. Nahed, H. G. and Khaled, A. A. M. (2012). Seroprevalence ‎of Coxiella burnetii antibodies among farm ‎animals and human contacts in Egypt. The Journal ‎of American Science, 8(3): 619–621. ‎
  99. Nakeel, M., Arimi, S., Kitala, P., Nduhiu, G., Njenga, J. ‎andWabacha, J. (2016).Asero-epidemiological ‎survey of brucellosis, Q fever and leptospirosis in ‎livestock and humans and associated risk factors in ‎Kajiado County. Journal of Tropical Diseases, ‎‎4(3): 123-130. https://doi.org/10.4172/2329-‎‎891X.1000215‎
  100. Nwanta, J. A., Onunkwo, J. I., Ezenduka, V. E., Phil-Eze, P. ‎O., and Egege, S. C. (2008). Abattoir operations and ‎waste management in Nigeria: A Review of ‎challenges and prospects. Sokoto Journal of ‎Veterinary Science, 7(2): 61-67.‎
  101. OIE, (2013). Except in New Zealand - World Organization ‎for animal health. Manual of diagnostic tests and ‎vaccines for terrestrial animals. Available from: ‎http://www. oie.int/international-standard ‎setting/terrestrial-manual/ Access-online. Accessed ‎on 13-06-2022.‎
  102. Omezzine-Letaief, A., Alaoui, F. Z., Bahri, F., Mahdhaoui, A. ‎and Boughzela, E. (2004). Infectious endocarditis ‎with negative blood cultures. Archives des maladies ‎du coeur et des vaisseaux, 97(2): 120–124. ‎
  103. Ormsbee, R., Peacock, M., Gerloff, G., Tallent, R. and Wike, ‎D. (1978). Limits of rickettsial infectivity. Infection ‎and Immunity, 19(1): 239-245. ‎https://doi.org/10.1128/iai.19.1.239-245.1978‎
  104. Peacock, M. G., Philip, R. N., Williams, J. C. and Faulkner, R. ‎S. (1983). Serological evaluation of O fever in ‎humans: enhanced phase I titers of ‎immunoglobulins G and A are diagnostic for Q ‎fever endocarditis. Infection and Immunity, 41(3): ‎‎1089–1098. https://doi.org/10.1128/iai.41.3.1089-‎‎1098.1983‎
  105. Pellegrin, M., Delsol, G., Auvergnat, J. C., Familiades, J., ‎Faure, H., Guiu, M. and Voigt, J. J. (1980). ‎Granulomatous hepatitis in Q fever. Human ‎Pathology, 11(1): 51–‎‎57. https://doi.org/10.1016/S0046-8177(80)80105-‎‎5‎
  106. Peter, O., Dupuis, G., Burgdorfer, W., Peacock, M. (1985). ‎Evaluation of the complement fixation and indirect ‎immunofluorescence tests in the early diagnosis of ‎primary Q fever. European Journal of Clinical ‎Microbiology &Infectious Diseases, 4: 394–396.‎
  107. Peter, O., Dupuis, G., Peacock, M. G., Burgdorfer, W. (1987). ‎Comparison of enzyme-linked immunosorbent ‎assay and complement fixation and indirect ‎fluorescent-antibody tests for detection of Coxiella ‎burnetii antibody. Journal of Clinical Microbiology, 25: 1063–1067.‎
  108. Peter, O., Dupuis, G., Bee, D., Luthy, R., Nicolet, J., ‎Burgdorfer, W. (1988). Enzyme-linked ‎immunosorbent assay for diagnosis of chronic Q ‎fever. Journal of Clinical Microbiology. 26: 1978–‎‎1982.‎
  109. Pierre-Edouard, F., Thomas, J. M. and Didier, R. (1998). ‎Diagnosis of Q Fever. Journal of Clinical ‎Microbiology. 36(7):1823–1834. ‎PMCID: PMC104936; PMID: 9650920‎
  110. Prabhu, M., Nicholson, W. L, Roche, A. J., Kersh, G. J. and ‎Fitzpatrick, K. A. (2011). Q fever, spotted fever ‎group, and typhus group rickettsioses among ‎hospitalized febrile patients in northern ‎Tanzania. Clinical Infectious Diseases 53: 8–15. ‎
  111. Qizilbash, A. H. (1983). The pathology of Q fever as seen on ‎liver biopsy. The Archives of Pathology & ‎Laboratory Medicine, 107: 364–367. ‎
  112. Radolakis A., Berri M., Hechard C., Caudron C., Souriau A., ‎Bodier C.C., Blanchard, B., Camuset, ‎P., Devillechaise, P., Natorp, J C., Vadet, J P. and N ‎Arricau-Bouvery. (2007). Comparison of Coxiella ‎burnetii shedding in milk of dairy bovine, caprine, ‎and ovine herds. Journal of Dairy Science 90 (12) ‎‎5352–5360. doi: 10.3168/jds.2006-815‎
  113. Raoult, D, Piquet, P., Gallais, H., de Micco, C., Drancourt, M. ‎and Casanova, P. (1986). Coxiella burnetii ‎infection of a vascular prosthesis. The New ‎England journal of medicine, 315(21): 1358–1359. ‎
  114. Raoult, D. (1990). Host factors in the severity of Q ‎fever. Annals of the New York Academy of ‎Sciences 590: 33-38.‎
  115. Raoult, D. and Marrie, T. (1995). Q fever. Clinical ‎Infectious Diseases. 20: 489–496. ‎
  116. Raoult, D., Tissot-Dupont, H.., Foucault, C., Gouvernet, J., ‎Fournier, P., P., Bernit, P., Stein, A., Nesri, M., Harlé, ‎J. and Weiller, P. (2000). Q fever 1985-1998. ‎Clinical and epidemiologic features of 1,383 ‎infections. Medicine (Baltimore) 79(2): 109-123. ‎https://doi.org/10.1097/00005792-200003000-‎‎00005‎
  117. Ratmanov, P., Bassene, H., Fenollar, F., Tall, A., Sokhna, C., ‎Raoult, D. and Mediannikov, O. (2013). The ‎correlation of Q fever and Coxiella burnetii DNA in ‎household environments in rural Senegal. Vector ‎Borne Zoonotic Diseases, 13(1): 70–72. ‎https://doi.org/10.1089/vbz.2012.1060..‎
  118. Rekiki, A., Thabti, F., Dlissi, I., Russo, P. andSanchis, R. ‎‎(2005). Seroprevalence survey of major infectious ‎abortive diseases in small ruminants in ‎Tunisia. Revue de ‎MedecineVeterinaire(Toulouse), 156: 395–401.‎
  119. Rodolakis, A., Berri, M., Héchard, C., Caudron, C., Souriau, ‎A., Bodier, C. C., Blanchard, B., Camuset, P., ‎Devillechaise, P., Natorp, J. C., Vadet, J. P. and ‎Arricau-Bouvery, N. (2007). Comparison of ‎Coxiella burnetii shedding in milk of dairy bovine, ‎caprine, and ovine herds. Journal of Dairy ‎Science, 90(2): 5352–5360. doi:10.3168/jds.2006-‎‎815. ‎
  120. Rubach, M. P.,Halliday, J. E., Cleaveland, S., Reddy, E. A. ‎and Crump, J. A. (2014). Epidemiology of Coxiella ‎burnetii infection in Africa: aOneHealth systematic ‎review. PLoSNegleted Tropical Diseases, 8(4): ‎‎ https://doi.org/10.1371/journal.pntd.0002787
  121. Saidu S. N. A., Umaru M. and Aliyu, S. U. (1991). ‎Husbandry, health management and socio – ‎economic practices of pastoralists in selected states ‎of Nigeria. Paper presented at the Nigerian Society ‎for Animal Production, Annual Conference held at ‎Sokoto, March, 1991.‎
  122. Sherry, A. M., Johnson, J. B., Kaneene, K. A.,William, ‎T.,Ivy, G., Mensah,K. A.,Shirley, V. and Simpson, ‎K. A. (2019). Seroprevalence of Q fever in cattle, ‎sheep and goats in the Volta region of Ghana. ‎Veterinary Medicine and Science, 5(3): 402-411 ‎https://doi.org/10.1002/vms3.160‎
  123. Schutte, A. P., Kurz, J., Barnard, B. J. and Roux, D. J. ‎‎(1976). Q fever in cattle and sheep in Southern ‎Africa. A preliminary report. OnderstepoortJournal ‎of Veterinary Research. 43: 129–132.‎
  124. Stein, A., and Raoult, D. (1995). Q fever ‎endocarditis. The European Heart Journal, 16: 19-‎‎23.‎
  125. Stocker, M., and Fiset, P. (1956). Phase variation of the nine ‎mile and other strains of Coxiella ‎burnetii. Canadian Journal of Microbiology, 2(3): ‎‎310-321. https://doi.org/10.1139/m56-036‎
  126. Tissot-Dupont, H., Thirion, X.andRaoult, D. (1994). Q fever ‎serology: cutoff determination for ‎microimmunofluorescence. Clinical and ‎diagnostic laboratory immunology, 1(2): 189-196. ‎
  127. Tissot-Dupont, H., Amadei, M. A., Nezri, M. and Raoult, D. ‎‎(2004). Wind in November, Q fever in ‎December. Emerging Infectious Diseases, 10(7): ‎‎1264–1269. ‎https://doi.org/10.3201/eid1007.030724. ‎
  128. ‎ Tissot-Dupont, H., Vaillant, V., Rey, S. andRaoult, D. ‎‎(2007). Role of sex, age, previous valve lesion, and ‎pregnancy in the clinical expression and outcome ‎of Q fever after a large outbreak. Clinical ‎Infectious Diseases,44(2): 232–237. ‎https://doi.org/10.1086/510389‎
  129. Tissot-Dupont, H. and Raoult, D. (2008). Q fever. Infectious ‎disease clinics of North America, 22(3): 505–514. ‎https://doi.org/10.1016/j.idc.2008.03.002‎
  130. Tokarevich N. K., Schramek S. and Daiter A. B. (1998). ‎Indirect haemolysis test in Q fever. Journal of ‎clinical microbiology, 36(7): 1823-1834. ‎https://doi.org/10.1128/JCM.36.7.1823-1834.1998‎
  131. Tukur, H. B., Ajogi, I., Kabir, J. and Umoh, J. U. (2014). ‎Seroprevalence of Coxiella burnetti in Cattle and ‎Its Risk Factors in Kaduna Metropolis, Kaduna ‎State, Nigeria. Journal of Agriculture and ‎Veterinary Science, 7(2):1–5. ‎https://doi.org/10.9790/2380-07210105‎
  132. Uhaa I. J., Fishbein, D. B., Olson, J. G., Rives, C. C., Waag, D. ‎M. and Williams J. C. (1994). Evaluation of ‎specificity of indirect enzyme-linked ‎immunosorbent assay for diagnosis of human Q ‎fever. Journal of Clinical Microbiology, 32(6): ‎‎1560–1565. pmid:8077404‎
  133. Van der Hoek, W., Dijkstra, F., Schimmer, B., Schneeberger, ‎P. M. andVellema, P. (2010). Q fever in the ‎Netherlands: an update on the epidemiology and ‎control measures. Eurosurveillance, 15(12): 19520.‎
  134. Vanderburg, S., Matthew, P. Rubach, Jo. E. B. ‎Halliday, Sarah Cleaveland, Elizabeth, A. Reddy ‎and John, A. Crump (2014). Epidemiology ‎of Coxiella burnetii Infection in Africa: A ‎OneHealth Systematic Review. PLoSNegleted ‎Tropical Diseases, ‎https://doi.org/10.1371/journal.pntd.0002787‎
  135. Webster, J. P., Lloyd, G. and Macdonald, D. W. (1995). Q ‎fever (Coxiella burnetii) reservoir in wild brown rat ‎‎(Rattus norvegicus) populations in the ‎UK. Parasitology, 110(1): 31–‎‎35. https://doi.org/10.1017/s0031182000081014‎
  136. Wielders C. C. H., van Loenhout, J. A. F., Morroy, G., ‎Rietveld, A., Notermans D. W., Wever, P. C., ‎Renders, N. H. M., Leenders, A. C. A. P., van der ‎Hoek, W. and Schneeberger, P. M. (2015). Long-‎term serological follow-up of acute Q-fever patients ‎after a large epidemic. PLOS ONE, ‎doi:10.1371/journal.pone.0131848. ‎
  137. Weir, W. R., Bannister, B., Chambers, S., De Cock, K., ‎Mistry, H. (1984).Chronic Q fever associated with ‎granulomatous hepatitis. Journal of Infection, 8(1): ‎‎56–60. https://doi.org/10.1016/S0163-‎‎4453(84)93354-1‎
  138. White, B., Brooks, T. and Seaton, R. A. (2013). Q fever in ‎military and paramilitary personnel in conflict ‎zones: case report and review. Travel Medicine and ‎Infectious Disease, 11(2): 134–137. ‎doi:10.1016/j.tmaid.2012.11.001. ‎
  139. Yakubu, Y. B. (2016). Seroprevalences of Brucella in small ‎ruminants, knowledge, attitude and practices of ‎small ruminants owners in Kaduna metropolis, ‎Kaduna State, Nigeria. MSc thesis to Ahmadu Bello ‎University, Zaria, Nigeria. 119 pages.‎
  140. Zeaiter, Z., Fournier, P. Greub, G. and D. Raoult (2003). ‎Diagnosis of Bartonella endocarditis by a real-time ‎nested-PCR assay using serum. Journal of Clinical ‎Microbiology, 41(3): 919-‎‎925. https://doi.org/10.1128/JCM.41.3.919-‎‎925.2003‎
  141. Zeman, D. H., Kirkbride, C. A., Leslie-Steen, P. and ‎Duimstra, J. R. (1989). Ovine abortion due to ‎Coxiella burnetii infection. The Journal of ‎Veterinary Diagnostic Investigation 1:178–180. ‎
  142. Znazen, A., Trabelsi, I., Maaloul, I., Gargouri, S. and ‎Maazoun, Y. (2009). Investigation of blood culture ‎negative endocarditis in a tertiary care centre in ‎Tunisia. International Journal of Antimicrobial ‎Agents, 33(2):89-95. ‎https://doi.org/10.1016/S0924-8579(09)70047-0‎