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Abstract

The potential of Abelmoschus esculentus leaf diet (AELD) in the reversal of Monosodium glutamate (MSG)-induced toxicity was assessed in this study. Eighteen (18) female Wistar rats (95±5 g) were equally divided into three (3) groups (n=6). Group A was the control (given I mL/kg distilled water) while Group B rats were exposed to MSG at 1000 mg/kg body weight for 60 days, and Group C was fed with a 20% AELD in the last 30 days of MSG exposure. On the 61st day, all rats were sacrificed with their liver, kidneys, heart, and femurs harvested for serum biochemistry assay, histology, and determination of micronuclei formation frequency. MSG caused a significant (p<0.05) and non-significant (p>0.05) increase in the body weight change compared to the control and AELD-treated groups, respectively. There was no significant (p>0.05) difference in the liver, relative total kidneys, and heart weights of rats in all the experimental groups. However, MSG significantly (p<0.05) and non-significantly (p>0.05) increased creatinine and BUN levels, respectively, in the MSG-treated group when compared to the control. These increases were reversed by AELD in the AELD-treated group. In addition, ALT activity was significantly (p<0.05) increased in the MSG-exposed group compared to other groups. AELD significantly suppressed this ALT activity, including the MSG-induced micronuclei formation and macrophage infiltration in the bone marrow. The histopathology induced by MSG in the liver, kidneys, and hearts were not completely reversed by AELD in the AELD-treated rats. In conclusion, this study shows that Abelmoschus esculentus is a potential anti-toxic agent in reversing MSG-induced anomalies in the liver, kidneys, heart, and bone marrow of treated rats.  

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Abelmoschus esculentus Monosodium glutamate Genotoxicity Histology

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Anti-toxic Effect of Abelmoschus esculentus Leaf Diet on Monosodium Glutamate-induced Organ Dysfunctions and Genotoxicity. (2026). Sahel Journal of Veterinary Sciences, 23(1), 9-15. https://doi.org/10.54058/2zka4805
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Anti-toxic Effect of Abelmoschus esculentus Leaf Diet on Monosodium Glutamate-induced Organ Dysfunctions and Genotoxicity. (2026). Sahel Journal of Veterinary Sciences, 23(1), 9-15. https://doi.org/10.54058/2zka4805

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