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Abstract
The hypoglycemic effect of feeding normal and alloxan-induced diabetic rats with Sweet Potato (Ipomoea batatas)and Irish Potato (Solanum tuberosum)flour fortified with vitamin for 21 days was studied. Forty-five white albino rats were divided into groups of five rats each. The groups are Normal control, Normal control + diet, positive control, negative control, test control 1 and test control 2. Fasting blood glucose and 2 hours post-prandial were measured at 7 days, 14 days and 21 days. It was found that sweet potato and irish potato flour diet significantly (P<0.05) reduced the fasting blood glucose and 2 hours post-prandial blood glucose compared with those of diabetic and normal rats fed with control diet. Maximum reduction in fasting and 2 hours post-prandial blood glucose was observed at day 21 with 119.6 ± 5.59 mmol/L in the sweet potato fed group compared to the diabetic control (223.6 ± 9.31mmol/L and normal control (106.6 ± 7.83) mmol/L. While the Irish potato group had (133 ± 2.45) mmol/L, compared to the diabetic control (233.6 ±9.31) mmol/L and normal control (106.6 ±7.83) mmol/L. However Sweet potato showed a better hypoglycemic effect than irish potato. This shows that the hypoglycemic effect of sweet and irish potato is time dependent.
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References
- Ahmed, O., Mahmoud, A., Abdel-Monein, A. and Ashour, M. (2012). Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats. DiabetologiaCroatica. 41:53-67.
- Astawan, M. and Widowati, S. (2011). Evaluation of nutrition and glycemic index of sweet potatoes and its appropriate processing to hypoglycemic foods. Indonesian Journal of Agricultural Science.,12(1):40-46. DOI: 10.21082/ijas.v12n1.2011
- Booker, L. and Yazdi, H. (2008). Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose: Summary of evidence report/technology assessment, No. 128. Agency for healthcare research and quality.
- Chandra, A., Singh, R.K. and Tiwari, L. (2004). Anti-oxidative potential of herbal hypoglycemic agents in diabetes. Indian Bulletin; 3 24-26.
- Gidado, A., Ameh, A., Atawodi, E. and Ibrahim, S. (2009). Antidiabetic effect of Nauclea Latifolia Leaf Ethanolic extract in Streptozotocin-induced diabetic Rats. PharmacognosyResearch. Vol 1. P 392-395.
- Idowu, M.A., Adeyemi, I.A., and David, M. (1992). Sensory evaluation and nutrient composition of a weaning food from pre-gelatinized maize and sweet potato mixture. Plant Foods for Human Nutrition. 44:149-55. Doi:10.1007/BF01088379.
- Kim, J., Choi, J., Lee, M., Kang, K., Park, M. and Jo, S. (2014). Immunomodulatory and antidiabetics effects of a new herbal preparation on Streptozotocin-induced diabetic mice. Evidence Based Complementary Alternative Medicine., pp1-8. DOI:101155/2014/461685
- Ludvik, B., Nueffer, B. and Pacini, G. (2004). Efficacy of Ipomea batatas (Caiapo) on diabetes control in type 2 subjects treated with diet. Diabetes Care. 27:436-40. Doi:10.2337/diacare.27.2.436.
- Nagarchi, K., Ahmed, S., Sabus, A. and Sabeb, S.H. (2015). Effect of Streptozotocin on Glucose levels in Albino Wister Rats. Journal of Pharmacological Science and Research. 7(2): 67-69.
- National Institutes of Health. NIH (2007). Memorandum of Understanding Between the Office of Laboratory Animal Welfare, National Institutes of Health, US Department of Health and Human Services and the Office of Research Oversight and the Office of Research and Development, Veterans Health Administration, US Department of Veterans Affairs Concerning Laboratory Animal Welfare. November 2007. Bethesda: Office of Extramural Research, NIH. Available at http://grants.nih.gov/grants/olaw/references/mou_olaw_va_2007_11.htm.
- Okon, J. E. and Ofeni, A.A. (2013). Antidiabetic Effect of Dioscuri Bulbiferous on Alloxan Induced Diabetic Rats. CIBTech. Journal of Pharmaceutical Sciences.,ISSN:2319-3891. Vol. 2(1). pp.14-19.
- Ramchander, T. Rajkumar, D., Stravanprasad, M., Venkateshwarlu, G. and Dhanalakshmi, A. (2012). Antidiabetic Activity of Aqeous Methanolic Extracts ofTamarinds Indica. International Journal of Pharmacological Research., 4(1):5-7
- Salih, N.D., Kamar, G.H., Noah, R.M and Muslih, R.K. (2014). The effect of streptozotocin induced diabetes mellitus on liver activity in mice. Global Journal on Advances in Pure and Applied Sciences. 3:67-75.
- Saydah, S.H., Miret, M., Sung, J., Varas, C., Gause, D. and Brancati, F.L. (2001). Post-challenge hyperglycemia and mortality in a national sample of U.S. Adults. Diabetes Care.24 (8):1397–402. Doi: 10.2337/diacare.24.8.1397.
- So, N. and Brand-Miller, J. (1999). The glycemic index of potatoes: The effect of variety, cooking method and maturity. European Journal Clinical Nutrition. 53: 249 254. DOI: 1038/SJ.EJCN.1600713
- Trout, D.L., Behall, K. M. and Osilesi, O. (1993). Prediction of glycemic index for starchy foods. American Journal of Clinical. Nutrition.58:873-8. Doi:10.1093/ajcn/58.6.873.
- Vosloo, C.M. (2005). Some factors affecting the digestion of glycemic carbohydrates and the blood glucose response. Journal of Family Ecology and Consumer Sciences. 33:1-9.
- Zeinab, A.E., Hawash, F. A. A. and Hanan, S. E. E. (2020). Effect of using sweet potato powder on diabetic rats. Home Economic. Journals. 36 (1): 12-15
References
Ahmed, O., Mahmoud, A., Abdel-Monein, A. and Ashour, M. (2012). Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats. DiabetologiaCroatica. 41:53-67.
Astawan, M. and Widowati, S. (2011). Evaluation of nutrition and glycemic index of sweet potatoes and its appropriate processing to hypoglycemic foods. Indonesian Journal of Agricultural Science.,12(1):40-46. DOI: 10.21082/ijas.v12n1.2011
Booker, L. and Yazdi, H. (2008). Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose: Summary of evidence report/technology assessment, No. 128. Agency for healthcare research and quality.
Chandra, A., Singh, R.K. and Tiwari, L. (2004). Anti-oxidative potential of herbal hypoglycemic agents in diabetes. Indian Bulletin; 3 24-26.
Gidado, A., Ameh, A., Atawodi, E. and Ibrahim, S. (2009). Antidiabetic effect of Nauclea Latifolia Leaf Ethanolic extract in Streptozotocin-induced diabetic Rats. PharmacognosyResearch. Vol 1. P 392-395.
Idowu, M.A., Adeyemi, I.A., and David, M. (1992). Sensory evaluation and nutrient composition of a weaning food from pre-gelatinized maize and sweet potato mixture. Plant Foods for Human Nutrition. 44:149-55. Doi:10.1007/BF01088379.
Kim, J., Choi, J., Lee, M., Kang, K., Park, M. and Jo, S. (2014). Immunomodulatory and antidiabetics effects of a new herbal preparation on Streptozotocin-induced diabetic mice. Evidence Based Complementary Alternative Medicine., pp1-8. DOI:101155/2014/461685
Ludvik, B., Nueffer, B. and Pacini, G. (2004). Efficacy of Ipomea batatas (Caiapo) on diabetes control in type 2 subjects treated with diet. Diabetes Care. 27:436-40. Doi:10.2337/diacare.27.2.436.
Nagarchi, K., Ahmed, S., Sabus, A. and Sabeb, S.H. (2015). Effect of Streptozotocin on Glucose levels in Albino Wister Rats. Journal of Pharmacological Science and Research. 7(2): 67-69.
National Institutes of Health. NIH (2007). Memorandum of Understanding Between the Office of Laboratory Animal Welfare, National Institutes of Health, US Department of Health and Human Services and the Office of Research Oversight and the Office of Research and Development, Veterans Health Administration, US Department of Veterans Affairs Concerning Laboratory Animal Welfare. November 2007. Bethesda: Office of Extramural Research, NIH. Available at http://grants.nih.gov/grants/olaw/references/mou_olaw_va_2007_11.htm.
Okon, J. E. and Ofeni, A.A. (2013). Antidiabetic Effect of Dioscuri Bulbiferous on Alloxan Induced Diabetic Rats. CIBTech. Journal of Pharmaceutical Sciences.,ISSN:2319-3891. Vol. 2(1). pp.14-19.
Ramchander, T. Rajkumar, D., Stravanprasad, M., Venkateshwarlu, G. and Dhanalakshmi, A. (2012). Antidiabetic Activity of Aqeous Methanolic Extracts ofTamarinds Indica. International Journal of Pharmacological Research., 4(1):5-7
Salih, N.D., Kamar, G.H., Noah, R.M and Muslih, R.K. (2014). The effect of streptozotocin induced diabetes mellitus on liver activity in mice. Global Journal on Advances in Pure and Applied Sciences. 3:67-75.
Saydah, S.H., Miret, M., Sung, J., Varas, C., Gause, D. and Brancati, F.L. (2001). Post-challenge hyperglycemia and mortality in a national sample of U.S. Adults. Diabetes Care.24 (8):1397–402. Doi: 10.2337/diacare.24.8.1397.
So, N. and Brand-Miller, J. (1999). The glycemic index of potatoes: The effect of variety, cooking method and maturity. European Journal Clinical Nutrition. 53: 249 254. DOI: 1038/SJ.EJCN.1600713
Trout, D.L., Behall, K. M. and Osilesi, O. (1993). Prediction of glycemic index for starchy foods. American Journal of Clinical. Nutrition.58:873-8. Doi:10.1093/ajcn/58.6.873.
Vosloo, C.M. (2005). Some factors affecting the digestion of glycemic carbohydrates and the blood glucose response. Journal of Family Ecology and Consumer Sciences. 33:1-9.
Zeinab, A.E., Hawash, F. A. A. and Hanan, S. E. E. (2020). Effect of using sweet potato powder on diabetic rats. Home Economic. Journals. 36 (1): 12-15