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Meytenus senengalensis (Lam). Ethanol leaf extract was investigated for its phytochemical contents as well as anti-diarrhoea effects. The ethanol leaf extract which is normally used in folkloric medicine was subjected to qualitative phytochemical screening. Graded doses of the extract (200, 400 and 800 mg per kg) were administered orally to the three groups of rats (n = 5) before induction of diarrhoea with castor oil. Another two groups of animals were treated with normal saline (control) and loperamide, a conventional anti-diarrhoea drug respectively. Gastro-intestinal transit of charcoal meal and gastro-intestinal enteropooling with the same graded doses of the ethanol leaf extract were used for comparison. The extract produced a significant inhibition of the castor oil induced diarrhoea. The gastro-intestinal transit of charcoal meal was also reduced by the various graded doses of the extract used in this study. However, the intestinal fluid accumulation was only slightly reduced by 400 mg/kg dose of the extract. The phytochemical analysis of the ethanol leaf extract revealed the presence of secondary metabolites such as   carbohydrates, cardenolides, cardiac glycosides, flavonoids, saponins, tannins and terpenoids. The findings suggest that, the ethanol leaf extract of M. senengalensis possesses antidiarrhoeal effect, which could be related to inhibition of gastro-intestinal motility and secretion.


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Author Biography

Kyari Abba Sanda, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Maiduguri.

Department of Veterinary Physiology and Biochemistry. Senior Lecture

How to Cite
Phytochemistry and effects of Ethanol Leaf Extract of Meytenus senengalensis (Lam) on Castor-oil Induced Diarrhoea in Albino Rats. (2020). Sahel Journal of Veterinary Sciences, 17(1), 1-6.

How to Cite

Phytochemistry and effects of Ethanol Leaf Extract of Meytenus senengalensis (Lam) on Castor-oil Induced Diarrhoea in Albino Rats. (2020). Sahel Journal of Veterinary Sciences, 17(1), 1-6.


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