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Abstract
Coxiellosis is a zoonotic disease caused by the obligate intracellular bacterium Coxiella burnetii which affect the prolific and reproductive competences of animals. A cross sectional study was conducted to determine the seroprevalence of coxiellosis (Q fever) in flocks of goats in Kaduna State, Nigeria.The study aimed to determinethe seroprevalence of coxiellosis in goats in Birnin Gwari and Maigana agro-ecological zone of Kaduna State, Nigeria. A total of 400serum samples from goats of both sexes and of different age groupswere collected and screened forCoxiella burnetiiantibodiesusing indirect enzyme-linked immunosorbent assay (iELISA).Out of the 400 sera analysed,8.8% wereseropositive coxiellosis. Of the 253 female goats tested, 9.5% were seropositive, while 7.5% were seropositive out of the 147 male goats tested. There was no statistically significant association between sex of goats and coxiellosis (Q fever). A significant association was detected betweenage of goatstested andsensitivity of iELISA, non-significantassociation was found between breed ofgoats with sensitivity of iELISA. The study indicates that coxiellosis exists with high prevalence predominantly among femalegoats and is major public health challenge calling for awareness amongstinterested party for organized surveillance for the diseases in goats in Nigeria.
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- Adamu, S.G., Kabir, J., Umoh, J.U and Raji, M.A. (2018). Seroprevalence of brucellosis and Q fever (coxiellosis) in cattle herds in Maigana and Birnin Gwari agro-ecological zone of Kaduna State, Nigeria. Trop. Anim. Health Prod.,50: 1583–1589.
- Adamu, S.G., Tijani, A.O., Adamu, N.B., Atsanda, N.N., Dauda, J. and Lawan, F.A. (2019). Epidemiology of Q - Fever in Flocks of Sheep in Yobe State, Nigeria. J. Vet. Biomed. Sci., 2(1): 70–76.
- Adesiyun, A.A., Jagun, A.G. and Tekdek, L.B. (1984). Coxiella burnetii antibodies in some Nigerian dairy cows and their suckling calves. Int. J. Zoonoses, 11(2):155–60.
- Astobiza, I., Barral, M., Ruiz‐Fons, F., Barandika, J.F., Gerrikagoitia, X., Hurtado, A. and Gardia‐Perez, A. L. (2011). Molecular investigation of the occurrence of Coxiella burnetii in wildlife and ticks in an endemic area, Vet. Microbiol., 147. 190–194.
- Bielawska-Drozd, A., Cieslik, P., Mirski, T., Gawel, J., Michalski, A., Niemcewicz, M., Bartoszcze, M., Zakowska, D., Lasocki, K., Knap, J. et al. (2014). Prevalence of Coxiella burnetii in environmental samples collected from cattle farms in Eastern and Central Poland (2011–2012). Vet. Microbiol., 174: 600–606.
- Cantas, H., Muwonge, A., Sareyyupoglu, B., Yardimci, H. and Skjerve, E. (2011). Q fever abortions in ruminants and associated on-farm risk factors in Northern Cyprus. BMCVet. Res., 7: 13.
- Chakrabartty, A., Bhattacharjee, P.K., Sarker, R.R., Rahman, A.K.M.A., Henning, K., Neubauer, H. and Rahman, M.S. (2016). Prevalence of Coxiella Burnetii Infection in Cattle, Black Bengal Goats and Ticks in Bangladesh. Bangl. J. Vet. Med., 14 (1): 65-68.
- Eldin C., Melenotte, C., Mediannikov, O., Ghigo, E., Million, M., Edouard, S. et al. (2017). From Q fever to Coxiella burnetii infection: a paradigm change. Clin. Microbiol. Rev., 30:115–190.
- Filioussis, G., Theodoridis, A., Papadopoulos, D., Gelasakis, A.I., Vouraki, S., Bramis, G. and Arsenos, G. (2017). Serological prevalence of Coxiella burnetii in dairy goats and ewes diagnosed with adverse pregnancy outcomes in Greece. Ann. Agr. Environ., 24(4): 702–705
- Guatteo, R., Seegers, H., Taurel, A.F., Joly, A. and Beaudeau, F. (2011). Prevalence of Coxiella burnetii infection in domestic ruminants: A critical review. Vet. Microbiol., 149:1–16.
- Hartzell, J.D., Wood-Morris, R.N., Martinez, L.J. and Trotta, R.F. (2008). Q fever: Epidemiology, diagnosis, and treatment. Mayo Clin. Proc., 83(5): 574–579.
- Hussien, M.O., ElFahal, A.M., Enan, K.A., Taha, K.M., Mohammed, M.S., Salih, D.A., Mohammadain, S.I., Saeed, A.A. and El-Hussein, A.M. (2012). Seroprevalence of Q fever in Goats of the Sudan. Vet. World, 5(7): 394–397.
- Jamagani, Z.B. (1998). Factors responsible for Farmers diversification of their cropping enterprises in some rural areas of Sabon Gari Local Government Area of Kaduna State Nigeria. PGD Thesis, Abubakar Tafawa Balewa University, Bauchi Pp 31, 1998.
- Johnson, S.A.M., Kaneene, J.B., Asare-Dompreh, K., Tasiame, W., Mensah, I.G., Afakye, K., Simpson, S.V. and Kwasi Addo, K. (2019). Seroprevalence of Q fever in cattle, sheep and goats in the Volta region of Ghana. Vet. Med. Sci., 5: 402–411
- Kaduna State Government (KDSG) (2008).“Kaduna State Achievements,” in data on estimated annual animal population and fish production investment opportunities in Kaduna State, 16–18.
- Karagul, M.S., Malal, M.E. and Akar, K. (2019). Seroprevalence of Q fever in sheep and goats from the Marmara region, Turkey. J. Vet. Res., 63: 527–532
- Kersh, G.K., Fitzpatrick, K.A., Self, J.S., Priestley, R.A., Kelly, A.J., Lash, R.R. et al. (2013). Presence and persistence of Coxiella burnetii in the environments of goat farms associated with a Q fever outbreak. Appl. Environ. Microbiol., 79: 1697–1703.
- Keyvani Rad, N., Azizzadeh, M., Taghavi-Razavizadeh, A.R., Mehrzad, J. and Rashtibaf M. (2013). Seroepidemiology of coxiellosis (Q fever) in sheep and goat population in the northeast of Iran. Iran. J. Vet. Res., 15(1): 1–16.
- Klaasen, M., Roest, H.J., Van der Hoek, W., Goossens, B., Secka, A. and Stegeman, A. (2014). Coxiella burnetii Seroprevalence in Small Ruminants in The Gambia. PLoS One,9(1): 1–6.
- Klemmer, J., Njeru, J., Emam, A., El-Sayed, A., Moawad, A.A., Henning, K., Elbeskawy, M.A., Sauter-Louis, C., Straubinger, R.K., Neubauer, H., et al. (2018). Q Fever in Egypt: Epidemiological Survey of Coxiella Burnetii Specific Antibodies in Cattle, Buffaloes, Sheep, Goats and Camels. PloS One, 13(2).
- Mohammed, O.B., Jarelnabi, A.M., Al-jumaah, R.S., Alshaikh, M.A., Bakheit, A.O., Omer, S.A., Alagaili, A.N. and Hussein, M.F. (2014). Coxiella burnetii, the causative agent of Q fever in Saudi Arabia: molecular detection from camel and other domestic livestock. Asian Pac. J. Trop. Med., 412–420.
- National population commission (NPC). National Population Census 2006 results. www.npc.ng. accessed on 12th November, 2017. 2006).
- Njeru, J., Henning, K., Pletz, M.W., Heller, R. and Neubauer, H. (2016) Q fever is an old and neglected zoonotic disease in Kenya: A systematic review. BMC Public Health, 16(1): 297–304.
- Raoult, D., T. Marrie, and J. Mege (2005). Natural history and pathophysiology of Q fever. Lancet Infect. Dis., 5: 219-226.
- Raphael, D. F, Opoku-Agyemang, T., Amemor, E., Opoku, E. D., Bentum, K. E. and Emikpe, B. O. (2020). Serological evidence of Coxiella burnetii infection in slaughtered sheep and goats at Kumasi Abattoir, Ghana. J. Immunoassay and Immunochemistry, 41: (2) 152-157.
- Ruiz-Fons, F., Astobiza, I., Barandika, J. F., Hurtado, A., Atxaerandio, R., Juste, R. A. and García-Pérez, A. L. (2010). Seroepidemiological study of Q fever in domestic ruminants in semi-extensive grazing systems. BMC Vet. Res., 6(3): 1746–6148.
- Salifu, S.P., Bukari, A.A., Frangoulidis, D. and Wheelhouse, N. (2019). Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa. Acta Tropica, 193(5): 99–105.
- Thrusfield, M. (2005). Veterinary epidemiology, 3rd ed. Oxford: Wiley Blackwell, 228- 330.
- Tukur, H.B., Ajogi, I., Kabir, J. and Umoh, J.U. (2014). Seroprevalence of Coxiella burnetii in cattle and its risk factors in Kaduna Metropolis, Kaduna State, Nigeria. J. Agr. Vet. Sci., 7(2): 1–5, 2014.
- Van den Brom, R., Van Engelen, E., Roest, H.I.J., van der Hoek, W. and Vellema, P. (2015). Coxiella burnetii infections in sheep or goats: an opinionated review. Vet. Microbiol., 181: 119–129.
- Van Leuken, J.P.G., Swart, A.N., Brandsma, J., Terink, W., Van de Kassteele, J., Droogers, P., Sauter, F., Havelaar, A.H. and Van der Hoek, W. (2016). Human Q fever incidence is associated to spatiotemporal environmental conditions. One Health, 2: 77–87.
- Ullah, Q., El-Adawy, H., Jamil, T., Jamil, H., Qureshi, Z.I., Saqib, M., Ullah, S. Shah, M.K., Khan, A.Z., Zubair, M., Khan, I., Mertens-Scholz, K., Henning, K. and Neubauer, H. (2019). Serological and Molecular Investigation of Coxiella burnetii in Small Ruminants and Ticks in Punjab, Pakistan. Int. J. Environ. Res. Public Health,16: 4271.
- Zahid, M.U., Hussain, M.H., Saqib, M., Neubauer, H., Abbas, G., Khan, I., Mansoor, M.K., Asi, M.N., Ahmad, T. and Muhammad, G. (2016). Seroprevalence of Q Fever (Coxiellosis) in Small Ruminants of Two Districts in Punjab, Pakistan. Vector-Borne and Zoonotic Dis., XX, Number XX, 1-6. DOI: 10.1089/vbz.2015.1852
References
Adamu, S.G., Kabir, J., Umoh, J.U and Raji, M.A. (2018). Seroprevalence of brucellosis and Q fever (coxiellosis) in cattle herds in Maigana and Birnin Gwari agro-ecological zone of Kaduna State, Nigeria. Trop. Anim. Health Prod.,50: 1583–1589.
Adamu, S.G., Tijani, A.O., Adamu, N.B., Atsanda, N.N., Dauda, J. and Lawan, F.A. (2019). Epidemiology of Q - Fever in Flocks of Sheep in Yobe State, Nigeria. J. Vet. Biomed. Sci., 2(1): 70–76.
Adesiyun, A.A., Jagun, A.G. and Tekdek, L.B. (1984). Coxiella burnetii antibodies in some Nigerian dairy cows and their suckling calves. Int. J. Zoonoses, 11(2):155–60.
Astobiza, I., Barral, M., Ruiz‐Fons, F., Barandika, J.F., Gerrikagoitia, X., Hurtado, A. and Gardia‐Perez, A. L. (2011). Molecular investigation of the occurrence of Coxiella burnetii in wildlife and ticks in an endemic area, Vet. Microbiol., 147. 190–194.
Bielawska-Drozd, A., Cieslik, P., Mirski, T., Gawel, J., Michalski, A., Niemcewicz, M., Bartoszcze, M., Zakowska, D., Lasocki, K., Knap, J. et al. (2014). Prevalence of Coxiella burnetii in environmental samples collected from cattle farms in Eastern and Central Poland (2011–2012). Vet. Microbiol., 174: 600–606.
Cantas, H., Muwonge, A., Sareyyupoglu, B., Yardimci, H. and Skjerve, E. (2011). Q fever abortions in ruminants and associated on-farm risk factors in Northern Cyprus. BMCVet. Res., 7: 13.
Chakrabartty, A., Bhattacharjee, P.K., Sarker, R.R., Rahman, A.K.M.A., Henning, K., Neubauer, H. and Rahman, M.S. (2016). Prevalence of Coxiella Burnetii Infection in Cattle, Black Bengal Goats and Ticks in Bangladesh. Bangl. J. Vet. Med., 14 (1): 65-68.
Eldin C., Melenotte, C., Mediannikov, O., Ghigo, E., Million, M., Edouard, S. et al. (2017). From Q fever to Coxiella burnetii infection: a paradigm change. Clin. Microbiol. Rev., 30:115–190.
Filioussis, G., Theodoridis, A., Papadopoulos, D., Gelasakis, A.I., Vouraki, S., Bramis, G. and Arsenos, G. (2017). Serological prevalence of Coxiella burnetii in dairy goats and ewes diagnosed with adverse pregnancy outcomes in Greece. Ann. Agr. Environ., 24(4): 702–705
Guatteo, R., Seegers, H., Taurel, A.F., Joly, A. and Beaudeau, F. (2011). Prevalence of Coxiella burnetii infection in domestic ruminants: A critical review. Vet. Microbiol., 149:1–16.
Hartzell, J.D., Wood-Morris, R.N., Martinez, L.J. and Trotta, R.F. (2008). Q fever: Epidemiology, diagnosis, and treatment. Mayo Clin. Proc., 83(5): 574–579.
Hussien, M.O., ElFahal, A.M., Enan, K.A., Taha, K.M., Mohammed, M.S., Salih, D.A., Mohammadain, S.I., Saeed, A.A. and El-Hussein, A.M. (2012). Seroprevalence of Q fever in Goats of the Sudan. Vet. World, 5(7): 394–397.
Jamagani, Z.B. (1998). Factors responsible for Farmers diversification of their cropping enterprises in some rural areas of Sabon Gari Local Government Area of Kaduna State Nigeria. PGD Thesis, Abubakar Tafawa Balewa University, Bauchi Pp 31, 1998.
Johnson, S.A.M., Kaneene, J.B., Asare-Dompreh, K., Tasiame, W., Mensah, I.G., Afakye, K., Simpson, S.V. and Kwasi Addo, K. (2019). Seroprevalence of Q fever in cattle, sheep and goats in the Volta region of Ghana. Vet. Med. Sci., 5: 402–411
Kaduna State Government (KDSG) (2008).“Kaduna State Achievements,” in data on estimated annual animal population and fish production investment opportunities in Kaduna State, 16–18.
Karagul, M.S., Malal, M.E. and Akar, K. (2019). Seroprevalence of Q fever in sheep and goats from the Marmara region, Turkey. J. Vet. Res., 63: 527–532
Kersh, G.K., Fitzpatrick, K.A., Self, J.S., Priestley, R.A., Kelly, A.J., Lash, R.R. et al. (2013). Presence and persistence of Coxiella burnetii in the environments of goat farms associated with a Q fever outbreak. Appl. Environ. Microbiol., 79: 1697–1703.
Keyvani Rad, N., Azizzadeh, M., Taghavi-Razavizadeh, A.R., Mehrzad, J. and Rashtibaf M. (2013). Seroepidemiology of coxiellosis (Q fever) in sheep and goat population in the northeast of Iran. Iran. J. Vet. Res., 15(1): 1–16.
Klaasen, M., Roest, H.J., Van der Hoek, W., Goossens, B., Secka, A. and Stegeman, A. (2014). Coxiella burnetii Seroprevalence in Small Ruminants in The Gambia. PLoS One,9(1): 1–6.
Klemmer, J., Njeru, J., Emam, A., El-Sayed, A., Moawad, A.A., Henning, K., Elbeskawy, M.A., Sauter-Louis, C., Straubinger, R.K., Neubauer, H., et al. (2018). Q Fever in Egypt: Epidemiological Survey of Coxiella Burnetii Specific Antibodies in Cattle, Buffaloes, Sheep, Goats and Camels. PloS One, 13(2).
Mohammed, O.B., Jarelnabi, A.M., Al-jumaah, R.S., Alshaikh, M.A., Bakheit, A.O., Omer, S.A., Alagaili, A.N. and Hussein, M.F. (2014). Coxiella burnetii, the causative agent of Q fever in Saudi Arabia: molecular detection from camel and other domestic livestock. Asian Pac. J. Trop. Med., 412–420.
National population commission (NPC). National Population Census 2006 results. www.npc.ng. accessed on 12th November, 2017. 2006).
Njeru, J., Henning, K., Pletz, M.W., Heller, R. and Neubauer, H. (2016) Q fever is an old and neglected zoonotic disease in Kenya: A systematic review. BMC Public Health, 16(1): 297–304.
Raoult, D., T. Marrie, and J. Mege (2005). Natural history and pathophysiology of Q fever. Lancet Infect. Dis., 5: 219-226.
Raphael, D. F, Opoku-Agyemang, T., Amemor, E., Opoku, E. D., Bentum, K. E. and Emikpe, B. O. (2020). Serological evidence of Coxiella burnetii infection in slaughtered sheep and goats at Kumasi Abattoir, Ghana. J. Immunoassay and Immunochemistry, 41: (2) 152-157.
Ruiz-Fons, F., Astobiza, I., Barandika, J. F., Hurtado, A., Atxaerandio, R., Juste, R. A. and García-Pérez, A. L. (2010). Seroepidemiological study of Q fever in domestic ruminants in semi-extensive grazing systems. BMC Vet. Res., 6(3): 1746–6148.
Salifu, S.P., Bukari, A.A., Frangoulidis, D. and Wheelhouse, N. (2019). Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa. Acta Tropica, 193(5): 99–105.
Thrusfield, M. (2005). Veterinary epidemiology, 3rd ed. Oxford: Wiley Blackwell, 228- 330.
Tukur, H.B., Ajogi, I., Kabir, J. and Umoh, J.U. (2014). Seroprevalence of Coxiella burnetii in cattle and its risk factors in Kaduna Metropolis, Kaduna State, Nigeria. J. Agr. Vet. Sci., 7(2): 1–5, 2014.
Van den Brom, R., Van Engelen, E., Roest, H.I.J., van der Hoek, W. and Vellema, P. (2015). Coxiella burnetii infections in sheep or goats: an opinionated review. Vet. Microbiol., 181: 119–129.
Van Leuken, J.P.G., Swart, A.N., Brandsma, J., Terink, W., Van de Kassteele, J., Droogers, P., Sauter, F., Havelaar, A.H. and Van der Hoek, W. (2016). Human Q fever incidence is associated to spatiotemporal environmental conditions. One Health, 2: 77–87.
Ullah, Q., El-Adawy, H., Jamil, T., Jamil, H., Qureshi, Z.I., Saqib, M., Ullah, S. Shah, M.K., Khan, A.Z., Zubair, M., Khan, I., Mertens-Scholz, K., Henning, K. and Neubauer, H. (2019). Serological and Molecular Investigation of Coxiella burnetii in Small Ruminants and Ticks in Punjab, Pakistan. Int. J. Environ. Res. Public Health,16: 4271.
Zahid, M.U., Hussain, M.H., Saqib, M., Neubauer, H., Abbas, G., Khan, I., Mansoor, M.K., Asi, M.N., Ahmad, T. and Muhammad, G. (2016). Seroprevalence of Q Fever (Coxiellosis) in Small Ruminants of Two Districts in Punjab, Pakistan. Vector-Borne and Zoonotic Dis., XX, Number XX, 1-6. DOI: 10.1089/vbz.2015.1852