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Abstract

Newcastle disease continues to pose serious public health and economic challenges to both small holder and commercial poultry worldwide. The aim of this study was to evaluate the most potent vaccine used in the control of Newcastle disease in pullets using different vaccination regimens. Two hundred- and twenty-five-day-old Isa brown pullets were purchased from a reputable hatchery at Ibadan, Nigeria. The chicks were divided into five groups of 45 chicks each. Groups A, B and C were divided into subgroups 1, 2 and 3 consisting of 15 chicks each. Group D was the negative control group which was neither vaccinated nor challenged while group E was the positive control group which was not vaccinated but challenged with Newcastle disease virus (Kudu 113, genotype XVII). The vaccines (La Sota, VG/GA and La Sota clone) were reconstituted as follows: each 1, 000 dose vial of vaccine was reconstituted with 5 ml of water; 0.1 ml of the dissolved vaccine was diluted in 300 ml of clean drinking water and administered to the birds via the oral route. Blood sampling was carried out using standard procedure and ELISA was carried out according to manufacturer’s instruction. There was presence of high maternally derived ND antibodies in the experimental chicks (12,627±1,806 - 17,722±1,607). The La Sota clone vaccine produced more antibodies (3,508±975) which was significantly different (p< 0.05) compared to VG/GA (737±439.77) vaccines. La Sota clone was able to confer 100% protection (p< 0.05) against Newcastle disease with no morbidity and mortality (0%). Vaccination at week 2 was the most effective (p< 0.05) for La Sota and La Sota clone strains but least for VG/GA strain of Newcastle disease vaccines.


 

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How to Cite
Evaluation of the Most Potent of Three Vaccines in Controlling Newcastle Disease in Pullets using different Vaccination Regimen. (2024). Sahel Journal of Veterinary Sciences, 21(2), 1-8. https://doi.org/10.54058/3ch01625

How to Cite

Evaluation of the Most Potent of Three Vaccines in Controlling Newcastle Disease in Pullets using different Vaccination Regimen. (2024). Sahel Journal of Veterinary Sciences, 21(2), 1-8. https://doi.org/10.54058/3ch01625

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